Post Doctoral Fellow

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Postdoctoral Research FellowSaint Louis University School of Medicine Department of Neurology

Project Title:Unraveling the Mechanisms of Alcohol-Induced Blood-Brain

Barrier Disruption: A Focus on Lipid Signaling and Endothelial Cells

Position Summary:Saint Louis University's Department of Neurology invites applications for a Postdoctoral Research Fellow to join our multidisciplinary team working on an NIH-funded project. The project investigates alcohol-induced cerebrovascular dysfunction, focusing on the role of lipid signaling in blood-brain barrier (BBB) disruption and neuroinflammation. The postdoctoral fellow will be involved in MCAO surgeries, biochemical analysis, and behavioral testing in a cutting-edge research environment. This position offers an opportunity to conduct innovative research on the effects of alcohol exposure on cerebrovascular health and neuroinflammation.

For more information on my research background and publications, please visit my ORCID profile: https://orcid.org/0000-0002-7691-8948.

Responsibilities:

• Perform Middle Cerebral Artery Occlusion (MCAO) surgeries to model ischemic stroke in mice.

• Conduct biochemical assays to analyze lipid signaling, enzyme expression, and oxidative stress markers in brain tissue.

• Perform Western blotting, PCR, immunohistochemistry, and fluorescence imaging.

• Coordinate and execute behavioral studies to assess cognitive and motor deficits, including Morris Water Maze (MWM), Novel Object Recognition (NOR), and Fear Conditioning Tests (FCT).

• Collaborate with laboratory team members on experimental design, data analysis, and manuscript preparation.

• Contribute to grant writing and publication of research findings in peer-reviewed journals.

Minimum Qualifications:

• A PhD in Neuroscience, Neurobiology, or a related field.

• Experience in surgical techniques, specifically MCAO, for stroke models in mice.

• Strong background in biochemical assays, including Western blotting, PCR, and immunohistochemistry.

• Experience with behavioral analysis in mice.

• First-author publication history in peer-reviewed journals.

• Strong communication skills and ability to collaborate with a diverse team of researchers.

Preferred Qualifications:

• Experience with lipid signaling, autotaxin, and LPP3 pathways in cerebrovascular research.

• Knowledge of animal models of neuroinflammation and ischemic stroke.

• Familiarity with neuroimaging techniques and data analysis tools (e.g., ImageJ, GraphPad Prism).

Position Details:

• Location: Saint Louis University School of Medicine, Department of Neurology, St. Louis, MO.

• Full-time, 40 hours/week.

• Compensation: Competitive salary with benefits.

How to Apply:

Interested candidates should submit the following materials to Dr. Manikandan Panchatcharam at manikandan.panchatcharam@health.slu.edu:

• Cover letter addressing qualifications and interest in the position.

• Curriculum Vitae (CV) with a list of publications.

• Contact information for three references.

Saint Louis University is an Equal Opportunity/Affirmative Action Employer. We encourage applications from individuals with disabilities, minorities, women, and veterans.

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Scheduled Weekly Hours:

Saint Louis University is an equal opportunity/affirmative action employer. All qualified candidates will receive consideration for the position applied for without regard to race, color, religion, sex, age, national origin, disability, marital status, sexual orientation, military/veteran status, gender identity, or other non-merit factors. If accommodations are needed for completing the application and/or with the interviewing process, please contact Human Resources at 314-977-5847.