New

Research Scientist I

Broad Institute
paid time off, paid holidays, 401(k), retirement plan
United States, Massachusetts, Cambridge
Jan 30, 2026
Description & Requirements Embedded within the Broad Institute of Harvard and MIT, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate the deep biological insights emerging from the Broad community into new therapeutics. To accomplish this mission, we partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry professionals in pharmaceutical, biotechnology and venture capital firms and advance cutting-edge drug discovery projects. We create new technologies and work to apply the unique capabilities of the Broad Institute to enable new therapeutic approaches that will broadly benefit the scientific community. We are seeking a highly motivated and capable Research Scientist I to join the Biochemistry & Biophysics group. As a lab-based position, the candidate will be responsible for the development, implementation and execution of biophysical assays utilizing state-of-the-art capabilities to advance drug discovery projects, and experience in this area is required. The successful candidate will be a results-focused, team-oriented, creative bench scientist. They must be self-motivated and detail-oriented, exhibiting strong problem-solving skills and the ability to excel in a fast-track environment. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with cross-functional project teams in identifying and achieving research goals. Responsibilities: Lead the development and execution of biophysical assays to support hit identification, validation, and lead optimization (e.g., SPR, BLI) Characterize recombinant proteins and their interactions using biochemical and biophysical assays (e.g., DSF, ITC, MST, and NMR) Design and execute research plans to ensure that critical project requirements, timelines and deliverables are met Troubleshoot and solve scientific problems independently Operate and maintain lab equipment independently Investigate and implement new technologies based on scientific needs Serve as the core biophysicist on cross-functional project teams, interpreting and communicating results in a clear and concise manner to academic and industry partners Ability to work with large datasets and maintain organized databases. Experience in biophysical characterization of biologics (e.g., antibodies, nanobodies, bispecifics) is beneficial, but not required. Qualifications: Ph.D. in Biochemistry, Biophysics, Structural biology or related life science field with 0-2+ years of relevant lab experience Biophysical assay development experience, with an advanced understanding of protein biochemistry and biophysics Significant experience with bioanalytical instrumentation and techniques, including SPR (Cytiva, Carterra), BLI, ITC, MST, and/or NMR Experience in recombinant protein expression and purification is desirable Ability to function productively with complete independence and maintain detailed lab records of experiments using a digital notebook (ELN) The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits. The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations. Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.