New

Scientist I

Spectraforce Technologies
United States, California, South San Francisco
Dec 04, 2025
Position Title: Scientist Work Location: South San Francisco, CA 94080 Assignment Duration: 06 Months Work Arrangement: Onsite Position Summary: The Quantitative, Translational ADME Sciences (QTAS) department at our organization is seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group. The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays for novel biologics entities. Key Responsibilities: Operate and maintain LC/MS instruments to generate high-quality experimental data. Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices. Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks. Facilitate assay optimization and implementation to ensure laboratory capacity and data quality. Communicate data interpretation internally and externally. Qualifications & Experience: Degree in chemistry, pharmacology or other related fields. BS/MS with 1 year of LC-MS (QQQ) experience or a fresh PhD with the right LC-MS experience, in a pharmaceutical industry setting with a focus on mass spectrometry. Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor. Prior industry experience in drug discovery/development is preferred. In-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired. Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is highly desired. Hands-on experience with automated liquid handling systems is highly desired. Hands-on experience with oligonucleotide analysis is highly desired. Degree in chemistry, pharmacology or other related fields. Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor Experience on routine LC/MS-based bioanalysis to support in vivo PK, TK, and PK/PD studies