Senior Scientist, Human Genetics & Targets

Internal Job Title: Senior Scientist I/Senior Scientist II

Position Location: onsite, Cambridge, MA

Your responsibilities include, but are not limited to:

• Identify and validate therapeutic targets for inflammatory diseases, investigate disease mechanisms, and develop novel drug candidates.

• Extensive experience in 2D/3D cell assays with cell lines, stem cells/iPS, primary or immune cells (macrophage/microglia), and advanced models like organoids and co-cultures to assess immune responses and cell interactions.

• Perform mechanism-of-action studies using molecular and cellular methods such as cytokine analysis, Western blotting, flow cytometry, qPCR, immunofluorescence, and barrier assays.

• Engineer human cell models using CRISPR and siRNA technologies for functional screening and/ mechanistic studies.

• Collaborate with cross-functional teams.

• Stay current with scientific literature and advancements, contribute to the publication of research findings and present at scientific conference.

• Mentor/train junior colleagues.

Minimum Requirements:

• B.S/M.S. in biological/biomedical sciences with a minimum of 7 years of hands-on experience in relevant fields; Recent Ph.D. graduates will also be considered.

• Proficiency in mammalian cell culture (primary, stem, immune, barrier models etc.) and experience with complex 2D/3D in vitro models, multicellular systems such as organoids.

• Solid background in molecular biology, immunology, and cell signaling, preferably with drug discovery experience in inflammatory or immune-related diseases.

• Strong written and verbal communication, organizational, and interpersonal skills.

• Proficient in problem-solving, data analysis, statistical/bioinformatics tools, and attention to detail.

• Able to work independently and collaboratively, adapt to shifting priorities, learning agility, and maintain a strong passion for science.

Desirable skills:

• Experience with advanced omics platforms such as spatial transcriptomics, single-cell RNA-seq or others, familiarity with machine learning, or systems biology approaches, population scale genetic datasets.

• Experience in conducting genetic functional studies using primary human or rodent cells, and in vivo murine inflammation models.

• Prior experience in inflammation research, particularly neuroinflammation or intestinal inflammation.

• Demonstrated track record of scientific publications and conference presentations.

The salary for this position is expected to range between $85,400 and $158,600 per year for Senior Scientist I, and $93,800 and $174,200 per year for Senior Scientist II.