Research Investigator - Sr. Research Investigator, Biologics Analytical Sciences

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)
This position will be mainly responsible for performing high resolution LC-MS analysis to characterize novel therapeutic monoclonal antibodies including bispecifics which are used for clinical studies and commercial launch. This is a hand-on position and requires solid scientific knowledge of LCMS for protein characterization and working experience with different high-resolution mass spectrometry platforms (Q-Tof and/or Orbitrap). Strong interpersonal and communication skills are required.

Essential Functions of the Job (Key responsibilities)

• Design and perform experiments for therapeutic proteins using high resolution LC-MS (Qtof and/or Orbitrap) including intact/reduced intact protein mass spec, reduced and non-reduced peptide mapping for characterizing protein primary structure, protein post-translational modifications, sequence variant analysis, and disulfide mapping.
• Record experiments in electronic laboratory notebook to ensure complying with our internal quality policy. Operate and maintain bioanalytical instrumentation in compliance with all safety rules and procedures.
• Interpret LCMS data and generate summary reports to support cell line development, process and formulation development, and comparability studies. Write detail technical reports of protein characterization and elucidation to support novel therapeutic monoclonal antibodies research and development.
• Monitor lab instrument performance weekly, track and order lab supplies when needed.
• Present data summaries and study conclusions at internal scientific meetings.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Expertise with protein mass spec especially mAb PTM characterization by LCMS is a must.
• Ph.D. in chemistry or related fields some relevant experience; Masters' degree with 3-5 years relevant experience; or Bachelors' degree in Biopharmaceuticals with >6 years' relevant experience.
• Working experience with Qtof instruments and/or Thermo Orbitrap is a plus.
• Critical thinking, strong written and verbal communication and organization skills are required.
• Willingness to work independently while collaborating with different functional groups is essential.
• Self-motivated with desire to learn new skills and highly organized with ability to work on multiple projects simultaneously.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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