Principal Scientist, Analytical Development - Oligonucleotides & Peptides

Job Description

General Summary:

As Vertex continues to expand its pipeline, in our commitment to serving patients, we are offering an exciting opportunity to join our Analytical Development team. We are actively seeking an analytical project leader to support small molecules, oligonucleotides, peptides, and conjugated therapeutics in Boston. This newly created position will be responsible for all aspects of analytical development related to both drug substance and drug product components of their assigned projects. The successful candidate will contribute significantly to advancing a product from the earliest stages of clinical development to marketing approval.

Key Duties and Responsibilities:

• Project Oversight: Oversee all analytical deliverables required to support clinical progression for assigned projects, including IND/IMPD submissions and information requests, as well as represent Analytical Development on cross-functional project teams. Manage analytical activities and timelines internally and externally at CROs/CDMOs.
• Strategy Development: Develop, align, and execute analytical project team plans and strategies to support drug substance and drug product development.
• Collaboration: Collaborate with all CMC functions and CMC leadership to develop strategies and deliver on key objectives; including managing matrixed analytical support of process and formulation activities.
• Technical Leadership: ensure successful method development/validation, release, and stability testing of drug substance and drug product.
• Mentorship: Mentor and train team members on laboratory practices and modality specific analytical techniques.

Knowledge and Skills:

• Demonstrated leadership experience in a pharmaceutical or biotechnology setting.
• CMC experience in pre-clinical and clinical development of small molecules, oligonucleotides, peptides, and/or conjugated therapeutics.
• Exceptional organizational, communication, leadership, and project management skills.
• Strong knowledge and experience with cGMPs and regulatory guidelines.
• Expertise with analytical techniques used in oligonucleotide and peptide therapeutics, such as LC-MS, IP-RP-LC, IEX, sequencing, and peptide mapping.

Education and Experience:

• Ph.D. with 4+ years, Master's degree with 7+ years, or BS degree with 10+ years of relevant experience within the pharmaceutical industry with an expertise in the development of small molecules, oligonucleotides and/or peptides.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com